Population Based Cancer Database By National Cancer Institute

The SEER is a population-based cancer database by National Cancer Institute. The SEER 13 represents approximately 14% of the population of the United States and includes 13 cancer registries - San Francisco-Oakland, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle (Puget Sound region), Utah, Atlanta, San Jose-Monterey, Los Angles, Alaska Natives, and rural Georgia. High quality data are collected from hospitals and cancer treatment centers. The database includes primary tumor site, staging, patient demographics, treatment modality and survival statistics (10). We selected adult patients (≠¥ 18 years) diagnosed with first primary HCC between January 1992 and December 2011. We excluded cases diagnosed at autopsy and those lost to†¦show more content†¦Results: A total of 15,296 patients diagnosed with primary HCC met the study criteria. Majority of the patients were men (74.47%) and belonged to the Caucacian race (58.57%). Median age at the time of diagnosis was 66.16 years (range: 42.33 - 95.5 years). Detailed patient demographics are presented in Table 1. The median follow-up duration was 28 months (range: 6 - 18.5 years). A total of 446 (2.83%) patients developed 466 SPM with observed/expected (O/E) ratio of 1.07 (95% CI= 0.97-1.17) and AER of 7.17 per 10,000 population, p = 0.16. These patients had significant excess risk of non-Hodgkin’s lymphoma and several solid tumors including cancers of head and neck, lung, thyroid, adrenal glands, stomach, anus and hepatobiliary region. Interestingly, there was significantly decreased risk of prostate cancer among HCC patients compared to general population. Younger patients (aged 60 years) had increased risk of malignancies of oropharynx (O/E ratio of 4.18, CI = 2.23 - 7.15, p=.01; AER 7.15), lung and bronchus (O/E ratio of 3.03, CI=1.9 - 4.58, p= 0.01; AER 11.6), hepatobiliary system (O/E ratio 4.35, CI=2.32-7.44, p=.01; AER 7.8), small intestine (O/E ratio of 8.11, CI=1.67-23.1, p=.01; AER 2.07), non-Hodgkin’s lymphoma (O/E ratio of 4.44, CI 2.43-7.44, p=.01; AER 8.53.) Among older patients (Age ≠¥ 60 years), there was increased risk of cancers of oropharynx (O/E ratio 1.7, CI